MOLECULAR ANALYSIS PROVIDES EVIDENCE FOR THE ENDOGENOUS ORIGIN OF BACTEREMIA AND MENINGITIS DUE TO ENTEROBACTER-CLOACAE IN AN INFANT

被引：28

作者：

LAMBERTZECHOVSKY, N

BINGEN, E

DENAMUR, E

BRAHIMI, N

BRUN, P

MATHIEU, H

ELION, J

机构：

[1] HOP ROBERT DEBRE,BIOCHIM GENET LAB,F-75019 PARIS,FRANCE

[2] HOP ROBERT DEBRE,SERV NEPHROL,F-75019 PARIS,FRANCE

来源：

CLINICAL INFECTIOUS DISEASES | 1992年 / 15卷 / 01期

关键词：

D O I：

10.1093/clinids/15.1.30

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We analyzed the restriction fragment length polymorphism (RFLP) of total DNA and of ribosomal DNA regions (ribotyping) to document the occurrence of endogenous, systemic bacteremia and meningitis due to Enterobacter cloacae in a newborn. Five strains of E. cloacae were isolated from this newborn. Three of these strains were recovered from stool at counts of 10(8), 10(9), and 10(9) organisms/g of feces, respectively; one strain was isolated from blood; and one strain was isolated from cerebrospinal fluid. In addition, five epidemiologically unrelated strains of E. cloacae were studied for comparison. Our study clearly shows the genetic relatedness of the strains isolated sequentially from cultures of stool, blood, and cerebrospinal fluid. RFLP analysis of total DNA and ribotyping seem particularly well suited to the study of the epidemiology of nosocomial E. cloacae strains.

引用

页码：30 / 32

页数：3

共 14 条

[1] TRANSLOCATION OF CERTAIN INDIGENOUS BACTERIA FROM THE GASTRO-INTESTINAL TRACT TO THE MESENTERIC LYMPH-NODES AND OTHER ORGANS IN A GNOTOBIOTIC MOUSE MODEL [J].