AN UNUSUALLY LARGE (CA)N REPEAT IN THE REGION OF DIVERGENCE BETWEEN SUBTELOMERIC ALLELES OF HUMAN CHROMOSOME-16P

被引:17
作者
WILKIE, AOM [1 ]
HIGGS, DR [1 ]
机构
[1] JOHN RADCLIFFE HOSP,INST MOLEC MED,MRC,MOLEC HAEMATOL UNIT,OXFORD OX3 9DU,ENGLAND
基金
英国医学研究理事会;
关键词
D O I
10.1016/0888-7543(92)90205-7
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Previous work has demonstrated discontinuous length variation at the tip of the short arm of human chromosome 16 (16pter) due to polymorphism of the subtelomeric region. We have now analyzed the zone where the two most common subtelomeric alleles (A and B) diverge. This lies 145 kb distal to the α-globin genes and comprises a complex segment of ∼4 kb where there is partial loss of homology between the alleles, preceding the final point of divergence. Most notably, there is an imperfect (CA)n repeat that differs in length with different 16pter alleles and is exceptionally large (n = 250-350) in the case of the A allele and homologous sequences on Xqter and Yqter. Both the (CA)n expansion and the genetic exchange between chromosomes 16, X, and Y seem to have occurred since the divergence of man from other great apes. The occurrence of long (CA)n tracts may be related to the biology of subtelomeric regions. © 1992.
引用
收藏
页码:81 / 88
页数:8
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