TRANSIENT ISCHEMIC CEREBRAL-LESIONS DURING INDUCTION CHEMOTHERAPY FOR ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：33

作者：

PIHKO, H ^{[1
]}

TYNI, T ^{[1
]}

VIRKOLA, K ^{[1
]}

VALANNE, L ^{[1
]}

SAINIO, K ^{[1
]}

HOVI, L ^{[1
]}

SAARINEN, UM ^{[1
]}

机构：

[1] UNIV HELSINKI, CHILDRENS HOSP, DEPT PEDIAT, SF-00290 HELSINKI 29, FINLAND

来源：

JOURNAL OF PEDIATRICS | 1993年 / 123卷 / 05期

关键词：

D O I：

10.1016/S0022-3476(05)80845-5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Ninety children were treated for acute lymphoblastic leukemia or non-Hodgkin lymphoma during 1986 through 1992 in the Children's Hospital, University of Helsinki, in Finland. During induction chemotherapy, nine of the children had visual hallucinations progressing to confusion and seizure. The symptoms were often preceded by severe constipation and significantly elevated blood pressure. Neuroradiologic examinations showed bilateral cortical or subcortical white matter lesions. Despite the strokelike manifestations, the lesions were reversible. The triangular shope and location of the lesions in the watershed areas between the major cerebral arteries suggest vascular ischemia as the cause.

引用

页码：718 / 724

页数：7

共 19 条

[1]

BYRD RL, 1981, CANCER, V47, P37, DOI 10.1002/1097-0142(19810101)47:1<37::AID-CNCR2820470108>3.0.CO

[2]

2-8

[3]

DIMARIO FJ, 1990, PEDIATRICS, V85, P353

[4] CEREBROVASCULAR COMPLICATIONS OF L-ASPARAGINASE THERAPY [J].

FEINBERG, WM ;

SWENSON, MR .

NEUROLOGY, 1988, 38 (01) :127-133

[5] ACUTE ENCEPHALOPATHY DURING INDUCTION THERAPY FOR ACUTE LYMPHOBLASTIC-LEUKEMIA [J].

GERRARD, MP ;

EDEN, OB ;

LILLEYMAN, JS .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1986, 3 (01) :49-58

[6]

GIBBY W A, 1989, AJNR, V10, pS78

[7] HYPERTENSIVE ENCEPHALOPATHY - MAGNETIC-RESONANCE IMAGING DEMONSTRATION OF REVERSIBLE CORTICAL AND WHITE MATTER LESIONS [J].

HAUSER, RA ;

LACEY, M ;

KNIGHT, MR .

ARCHIVES OF NEUROLOGY, 1988, 45 (10) :1078-1083

[8] CORTICAL BLINDNESS DURING CHEMOTHERAPY - CLINICAL, CT, AND MR CORRELATIONS [J].

HERAN, F ;

DEFER, G ;

BRUGIERES, P ;

BRENOT, F ;

GASTON, A ;

DEGOS, JD .

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1990, 14 (02) :262-266

[9] REVERSIBLE ENCEPHALOPATHY AND SEIZURES AS A RESULT OF CONVENTIONAL VINCRISTINE ADMINISTRATION [J].

HURWITZ, RL ;

MAHONEY, DH ;

ARMSTRONG, DL ;

BROWDER, TM .

MEDICAL AND PEDIATRIC ONCOLOGY, 1988, 16 (03) :216-219

[10]

INGELFINGER JR, 1989, MOSS HEART DISEASE I, P1016

← 1 2 →