A 405-KB COSMID CONTIG AND HINDIII RESTRICTION MAP OF THE PROGRESSIVE MYOCLONUS EPILEPSY TYPE-1 (EPM1) CANDIDATE REGION IN 21Q22.3

被引：21

作者：

LAFRENIERE, RG

DEJONG, PJ

ROULEAU, GA

机构：

[1] MCGILL UNIV,CTR RES NEUROSCI,MONTREAL,PQ H3G 1A4,CANADA

[2] ROSWELL PK CANC INST,DEPT HUMAN GENET,BUFFALO,NY 14263

来源：

GENOMICS | 1995年 / 29卷 / 01期

关键词：

D O I：

10.1006/geno.1995.1248

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

As a step toward identifying the molecular defect in patients afflicted with progressive myoclonus epilepsy type 1 (EPM1), we have assembled a cosmid contig of the candidate EPM1 region in 21q22.3. The contig constitutes a collection of 87 different cosmids spanning 405 kb based on a derived HindIII restriction map. Potential CpG-rich islands have been identified based on the restriction map generated from eight different rare-cutting enzymes. This contig contains the genetic material required for the isolation of expressed sequences and the identification of the gene defective in EPM1 and possibly other disorders mapping to this region. (C) 1995 Academic Press, Inc.

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页码：288 / 290

页数：3

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