4 NEW DIMERIC PEPTIDE ALKALOIDS, ANCHINOPEPTOLIDES-B-D, AND CYCLOANCHINOPEPTOLIDE-C, CONGENERS OF ANCHINOPEPTOLIDE-A, FROM THE MEDITERRANEAN MARINE SPONGE ANCHINOE-TENACIOR

被引:32
作者
CASAPULLO, A [1 ]
MINALE, L [1 ]
ZOLLO, F [1 ]
LAVAYRE, J [1 ]
机构
[1] UNIV NAPLES,DIPARTIMENTO CHIM SOSTANZE NAT,I-80131 NAPLES,ITALY
来源
JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 09期
关键词
D O I
10.1021/np50111a006
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Following the characterization of anchinopeptolide A [1], three new conge netic dimeric peptide alkaloids, named anchinopeptolides B [2], C [3], and D [4], have been isolated from the Mediterranean sponge Anchinoe tenacior. A fourth compound, cycloanchinopeptolide C [5], which is related to anchinopeptolide C [5] by a head-to-head intramolecular [2+2] cycle-addition reaction, has also been isolated. The structures of these peptide alkaloids have been elucidated on the basis of spectral evidence. Anchinopeptolides bind to the somatostatin, human B2 bradykinin, and neuropeptide Y receptors.
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收藏
页码:1227 / 1233
页数:7
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