SIGNAL-TRANSDUCTION MECHANISMS SUBSERVING ACTIVITY-DEPENDENT RELEASE OF NEURONAL PROTEOGLYCANS

被引：6

作者：

DOW, KE

SUGIURA, M

机构：

[1] QUEENS UNIV, DEPT PEDIAT, KINGSTON, ON K7L 2V7, CANADA

[2] TEIKYO UNIV, SCH MED, DEPT PEDIAT, TOKYO 173, JAPAN

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1995年 / 89卷 / 02期

基金：

英国医学研究理事会;

关键词：

GLUTAMATE; PROTEOGLYCAN; SIGNAL TRANSDUCTION; NITRIC OXIDE; PROTEIN KINASE C; CALCIUM-CALMODULIN TYPE II KINASE;

D O I：

10.1016/0165-3806(95)00127-Y

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We demonstrate here using dissociated hippocampal neurons that glutamate-induced release of proteoglycans which have been shown to have neurite growth-promoting activity is regulated by serine/threonine kinases of the protein kinase C and calcium/calmodulin type II kinase families, and that the state of phosphorylation of hippocampal neurons is a determinant of the magnitude and duration of the release response. Nitric oxide is also involved in mediating glutamate-induced PG release.

引用

页码：320 / 324

页数：5

共 36 条

[1] INDUCTION OF LTP IN THE HIPPOCAMPUS NEEDS SYNAPTIC ACTIVATION OF GLUTAMATE METABOTROPIC RECEPTORS [J].