GASTRIC ANTISECRETORY, ANTIULCER AND CYTOPROTECTIVE PROPERTIES OF ETHANOLIC EXTRACT OF ALPINIA-GALANGA WILLD IN RATS

被引：27

作者：

ALYAHYA, MA ^{[1
]}

RAFATULLAH, S ^{[1
]}

MOSSA, JS ^{[1
]}

AGEEL, AM ^{[1
]}

ALSAID, MS ^{[1
]}

TARIQ, M ^{[1
]}

机构：

[1] KING SAUD UNIV, COLL PHARM, MED AROMAT & POISONOUS PLANTS RES CTR, RIYADH 11451, SAUDI ARABIA

来源：

PHYTOTHERAPY RESEARCH | 1990年 / 4卷 / 03期

关键词：

Alpinia galanga; cytoprotection; gastric secretion; gastric ulcers; gastric wall mucus;

D O I：

10.1002/ptr.2650040308

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of Alpinia galanga extract has been studied on experimentally induced gastric ulcers in rats. The ethanolic extract of A. galanga at a dose of 500 mg/kg, significantly reduced the intensity of gastric mucosal damage induced by pyloric ligation and hypothermic restraint stress in rats. It produced a significant decrease in gastric secretion in pylorus ligated rats and a highly significant cytoprotective effect against 80% ethanol‐, 0.6 M HCI‐, 0.2 M NaOH‐ and 25% NaCl‐induced cytodestruction. Pretreatment with the extract significantly prevented hypothermic stress‐induced gastric wall mucus depletion. These findings suggest that a significant antisecretory and cytoprotective action of A. galanga may be responsible for its antiulcer activity. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：112 / 114

页数：3

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