DIFFERENTIAL RECOVERY OF DOPAMINE SYNTHETIC ENZYMES FOLLOWING MPTP AND THE CONSEQUENCES OF GM1 GANGLIOSIDE TREATMENT

被引：25

作者：

HADJICONSTANTINOU, M

NEFF, NH

机构：

[1] OHIO STATE UNIV,COLL MED,DEPT PHARMACOL,333 W 10TH AVE,COLUMBUS,OH 43210

[2] OHIO STATE UNIV,COLL MED,DEPT PSYCHIAT,COLUMBUS,OH 43210

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 181卷 / 1-2期

关键词：

Aromatic L-amino acid decarboxylase (AAAD); GM1; ganglioside; MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine); Striatum; Tyrosine hydroxylase;

D O I：

10.1016/0014-2999(90)90255-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

After 7 days of treatment with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), 30 mg/kg i.p., tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD) activities are decreased by more than 50% in the mouse striatum. Within 30 days, AAAD activity returns while TH activity remains depressed. TH activity can be restored to near normal by chronic treatment with GM1 ganglioside, 30 mg/kg i.p. © 1990.

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收藏

页码：137 / 139

页数：3

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