A METHOD TO DETECT AND CHARACTERIZE POINT MUTATIONS IN TRANSCRIBED GENES - AMPLIFICATION AND OVEREXPRESSION OF THE MUTANT C-KI-RAS ALLELE IN HUMAN-TUMOR CELLS

被引：359

作者：

WINTER, E ^{[1
]}

YAMAMOTO, F ^{[1
]}

ALMOGUERA, C ^{[1
]}

PERUCHO, M ^{[1
]}

机构：

[1] SUNY STONY BROOK, DEPT BIOCHEM, STONY BROOK, NY 11794 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1985年 / 82卷 / 22期

关键词：

D O I：

10.1073/pnas.82.22.7575

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：7575 / 7579

页数：5

共 14 条

[1] ACTIVATION OF KI-RAS 2 GENE IN HUMAN-COLON AND LUNG CARCINOMAS BY 2 DIFFERENT POINT MUTATIONS [J].

CAPON, DJ ;

SEEBURG, PH ;

MCGRATH, JP ;

HAYFLICK, JS ;

EDMAN, U ;

LEVINSON, AD ;

GOEDDEL, DV .

NATURE, 1983, 304 (5926) :507-513

[2] ANALYSIS OF THE TRANSFORMING POTENTIAL OF THE HUMAN H-RAS GENE BY RANDOM MUTAGENESIS [J].

FASANO, O ;

ALDRICH, T ;

TAMANOI, F ;

TAPAROWSKY, E ;

FURTH, M ;

WIGLER, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (13) :4008-4012

[3] CELLULAR ONCOGENES AND MULTISTEP CARCINOGENESIS [J].

LAND, H ;

PARADA, LF ;

WEINBERG, RA .

SCIENCE, 1983, 222 (4625) :771-778

[4]

MELTON DA, 1984, NUCLEIC ACIDS RES, V12, P7035, DOI 10.1093/nar/12.18.7035

[5] 3 DIFFERENT HUMAN-TUMOR CELL-LINES CONTAIN DIFFERENT ONCOGENES [J].

MURRAY, MJ ;

SHILO, BZ ;

SHIH, C ;

COWING, D ;

HSU, HW ;

WEINBERG, RA .

CELL, 1981, 25 (02) :355-361

[6] DETECTION OF SINGLE BASE SUBSTITUTIONS IN TOTAL GENOMIC DNA [J].

MYERS, RM ;

LUMELSKY, N ;

LERMAN, LS ;

MANIATIS, T .

NATURE, 1985, 313 (6002) :495-498

[7] ISOLATION OF TRANSFORMING SEQUENCES OF 2 HUMAN-LUNG CARCINOMAS - STRUCTURAL AND FUNCTIONAL-ANALYSIS OF THE ACTIVATED C-K-RAS ONCOGENES [J].

NAKANO, H ;

YAMAMOTO, F ;

NEVILLE, C ;

EVANS, D ;

MIZUNO, T ;

PERUCHO, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (01) :71-75

[8] HUMAN-TUMOR-DERIVED CELL-LINES CONTAIN COMMON AND DIFFERENT TRANSFORMING GENES [J].

PERUCHO, M ;

GOLDFARB, M ;

SHIMIZU, K ;

LAMA, C ;

FOGH, J ;

WIGLER, M .

CELL, 1981, 27 (03) :467-476

[9] BIOLOGICAL PROPERTIES OF HUMAN C-HA-RAS 1 GENES MUTATED AT CODON-12 [J].

SEEBURG, PH ;

COLBY, WW ;

CAPON, DJ ;

GOEDDEL, DV ;

LEVINSON, AD .

NATURE, 1984, 312 (5989) :71-75

[10] BIOCHEMICAL METHOD FOR MAPPING MUTATIONAL ALTERATIONS IN DNA WITH S1 NUCLEASE - LOCATION OF DELETIONS AND TEMPERATURE-SENSITIVE MUTATIONS IN SIMIAN VIRUS 40 [J].

SHENK, TE ;

RHODES, C ;

RIGBY, PWJ ;

BERG, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (03) :989-993

← 1 2 →