PREPARATIVE-SCALE ENANTIOSEPARATION OF A CHIRAL EPOXIDE - COMPARISON OF LIQUID-CHROMATOGRAPHY AND SIMULATED MOVING-BED ADSORPTION TECHNOLOGY

被引：97

作者：

NICOUD, RM

FUCHS, G

ADAM, P

BAILLY, M

KUSTERS, E

ANTIA, FD

REUILLE, R

SCHMID, E

机构：

[1] SANDOZ PHARMA AG,DEPT CHEM PROC RES & DEV,CH-4002 BASEL,SWITZERLAND

[2] SEPAREX,CHAMPIGNEUILLES,FRANCE

来源：

CHIRALITY | 1993年 / 5卷 / 04期

关键词：

SIMULATED MOVING BED TECHNOLOGY; CHIRAL SEPARATION; CELLULOSE TRIACETATE; PREPARATIVE SCALE LIQUID CHROMATOGRAPHY; RACEMIC EPOXIDE;

D O I：

10.1002/chir.530050415

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The feasibility of using simulated moving bed technology (SMB) for chiral separation on cellulose triacetate is demonstrated on the preparative scale: 1 kg of a chiral epoxide has been separated. On comparing SMB technology with conventional liquid chromatography it turns out that the main advantage of SMB lies in the significant reduction of mobile phase consumption. The process design for SMB is made theoretically and the predictions are confirmed by our pilot study. (C) 1993 Wiley-Liss, Inc.

引用

页码：267 / 271

页数：5

共 8 条

[1] Broughton D.B., 1961, U.S. Patent, Patent No. [2,985,589, 2985589]
[2] BROUGHTON DB, 1972, Patent No. 3636180
[3] Broughton DB, 1965, US Patent, Patent No. [3,214,247, 3214247]
[4] BROUGHTON DB, 1966, Patent No. 3291726
[5] FUCHS G, 1992, 9TH P S PREP IND CHR, P395
[6] OPTICAL RESOLUTION BY SIMULATED MOVING-BED ADSORPTION TECHNOLOGY
NEGAWA, M
SHOJI, F
[J]. JOURNAL OF CHROMATOGRAPHY, 1992, 590 (01): : 113 - 117
[7] Nicoud R. M., 1992, LC-GC International, V5, P43
[8] Rosset A.J., 1972, U.S. Patent, Patent No. [US 3706812 A, 3706812]

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