REPLACEMENT OF THE PHOSPHODIESTER LINKAGE IN OLIGONUCLEOTIDES - COMPARISON OF 2 STRUCTURAL AMIDE ISOMERS

被引：31

作者：

DEMESMAEKER, A

LEBRETON, J

WALDNER, A

FRITSCH, V

WOLF, RM

机构：

[1] Central Research Laboratories, CIBA-GEIGY Ltd.

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)80254-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The two structural amide isomers 2 and 3 as backbone replacement in oligonucleotides lead to very similar results for the binding affinities (T-m) of the duplexes formed with their complementary RNA strands.

引用

页码：873 / 878

页数：6

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