ASYMMETRIC-SYNTHESIS AND ABSOLUTE STEREOCHEMISTRY OF CHOLESTEROL ABSORPTION INHIBITOR, SCH-48461

被引：56

作者：

BURNETT, DA

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ 07033-0539

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 40期

关键词：

D O I：

10.1016/0040-4039(94)85308-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first asymmetric synthesis of cholesterol absorption inhibitor, SCH 48461 is described. The compound was prepared from an asymmetric ester enolate-imine condensation using Oppolzer's chiral ester or the corresponding menthol ester as the stereocontrolling element. From analogy to literature examples, the absolute stereochemistry of the title compound was assigned to be 3R, 4S.

引用

页码：7339 / 7342

页数：4

共 5 条

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