HLA CLASS-II GENES ASSOCIATED WITH ANTICENTROMERE ANTIBODY IN JAPANESE PATIENTS WITH SYSTEMIC-SCLEROSIS (SCLERODERMA)

被引:32
作者
KUWANA, M
OKANO, Y
KABURAKI, J
INOKO, H
机构
[1] KEIO UNIV,SCH MED,DEPT MED,DIV RHEUMATOL,TOKYO 160,JAPAN
[2] NIPPON KOKAN LTD CO HOSP,DEPT INTERNAL MED,KAWASAKI,KANAGAWA,JAPAN
[3] TOKAI UNIV,SCH MED,DEPT GENET INFORMAT,DIV MOLEC LIFE SCI,ISEHARA,KANAGAWA 25911,JAPAN
关键词
D O I
10.1136/ard.54.12.983
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-To define further HLA class II gene associations with anticentromere antibody (ACA), a major serum antinuclear antibody in patients with systemic sclerosis (SSc). Methods-HLA class II genes were determined using polymerase chain reaction/ restriction fragment length polymorphisms in 94 Japanese patients with SSc (22 ACA positive and 72 ACA negative) and 50 race matched normal control subjects. Results-Frequency of DQB1*0501 was increased in ACA positive SSc patients compared with ACA negative SSc patients (36% versus 13%; p = 0.02, odds ratio = 4.0, 95% confidence interval 1.1 to 13.9), but the association of ACA with a polar amino acid at position 26 in the DQB1 pi domain, which was demonstrated in white North Americans, was not observed in Japanese. The DRB1*0101, *0405, and *1302 alleles were associated with high ACA titres, whereas DRB1*1502 was associated with low ACA titres and a low frequency of centromere protein C (CENP-C) reactivity. Conclusions-These results suggest that the ACA response is associated with multiple HLA class II genes and that ACA positive SSc patients are heterogeneous in terms of immunogenetic background.
引用
收藏
页码:983 / 987
页数:5
相关论文
共 21 条
[1]   INJECTION OF ANTICENTROMERE ANTIBODIES IN INTERPHASE DISRUPTS EVENTS REQUIRED FOR CHROMOSOME MOVEMENT AT MITOSIS [J].
BERNAT, RL ;
BORISY, GG ;
ROTHFIELD, NF ;
EARNSHAW, WC .
JOURNAL OF CELL BIOLOGY, 1990, 111 (04) :1519-1533
[2]   A MOLECULAR AND SEROLOGIC ANALYSIS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX AND COMPLEMENT COMPONENT-C4 IN SYSTEMIC-SCLEROSIS [J].
BRIGGS, D ;
STEPHENS, C ;
VAUGHAN, R ;
WELSH, K ;
BLACK, C .
ARTHRITIS AND RHEUMATISM, 1993, 36 (07) :943-957
[3]   DNA-DR TYPING SHOWS HLA-DRW11 RFLPS ARE INCREASED IN FREQUENCY IN BOTH PROGRESSIVE SYSTEMIC-SCLEROSIS AND CREST VARIANTS OF SCLERODERMA [J].
DUNCKLEY, H ;
JAZWINSKA, EC ;
GATENBY, PA ;
SERJEANTSON, SW .
TISSUE ANTIGENS, 1989, 33 (03) :418-420
[4]   3 HUMAN CHROMOSOMAL AUTOANTIGENS ARE RECOGNIZED BY SERA FROM PATIENTS WITH ANTICENTROMERE ANTIBODIES [J].
EARNSHAW, W ;
BORDWELL, B ;
MARINO, C ;
ROTHFIELD, N .
JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (02) :426-430
[5]   MOLECULAR-CLONING OF CDNA FOR CENP-B, THE MAJOR HUMAN CENTROMERE AUTOANTIGEN [J].
EARNSHAW, WC ;
SULLIVAN, KF ;
MACHLIN, PS ;
COOKE, CA ;
KAISER, DA ;
POLLARD, TD ;
ROTHFIELD, NF ;
CLEVELAND, DW .
JOURNAL OF CELL BIOLOGY, 1987, 104 (04) :817-829
[6]   IMMUNOGENETIC ASSOCIATIONS OF SCLERODERMA-RELATED ANTINUCLEAR ANTIBODIES [J].
GENTH, E ;
MIERAU, R ;
GENETZKY, P ;
VONMUHLEN, CA ;
KAUFMANN, S ;
VONWILMOWSKY, H ;
MEURER, M ;
KRIEG, T ;
POLLMANN, HJ ;
HARTL, PW .
ARTHRITIS AND RHEUMATISM, 1990, 33 (05) :657-665
[7]  
INOKO H, 1993, HDB HLA TYPING TECHN, P9
[8]   CLINICAL AND PROGNOSTIC ASSOCIATIONS BASED ON SERUM ANTINUCLEAR ANTIBODIES IN JAPANESE PATIENTS WITH SYSTEMIC-SCLEROSIS [J].
KUWANA, M ;
KABURAKI, J ;
OKANO, Y ;
TOJO, T ;
HOMMA, M .
ARTHRITIS AND RHEUMATISM, 1994, 37 (01) :75-83
[9]   THE HLA-DR AND DQ GENES CONTROL THE AUTOIMMUNE-RESPONSE TO DNA TOPOISOMERASE-I IN SYSTEMIC-SCLEROSIS (SCLERODERMA) [J].
KUWANA, M ;
KABURAKI, J ;
OKANO, Y ;
INOKO, H ;
TSUJI, K .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (03) :1296-1301
[10]   MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II GENE ASSOCIATIONS WITH ANTI-U1 SMALL NUCLEAR RIBONUCLEOPROTEIN ANTIBODY - RELATIONSHIP TO IMMUNOREACTIVITY WITH INDIVIDUAL CONSTITUENT PROTEINS [J].
KUWANA, M ;
OKANO, Y ;
KABURAKI, J ;
TSUJI, K ;
INOKO, H .
ARTHRITIS AND RHEUMATISM, 1995, 38 (03) :396-405