STRUCTURAL ALTERATIONS AT THE PUTATIVE RETINOBLASTOMA LOCUS IN SOME HUMAN LEUKEMIAS AND PRELEUKEMIA

被引：23

作者：

HANSEN, MF

MORGAN, R

SANDBERG, AA

CAVENEE, WK

机构：

[1] SW BIOMED RES INST,CTR CANC,SCOTTSDALE,AZ

[2] LUDWIG INST CANC RES,MONTREAL,QUEBEC,CANADA

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 49卷 / 01期

关键词：

D O I：

10.1016/0165-4608(90)90159-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Homozygous loss of alleles of the retinoblastoma susceptibility locus (RB1) has been implicated in the onset of many different solid tumors. Heterozygous deletions of chromosome 13q14, the region containing the RB1 locus, have been observed by us in several subvariants of leukemia and preleukemia. We examined four cases of leukemia and one case of preleukemia for homozygous inactivation of the RB1 locus; in at least one case, evidence supports the concept that homozygous loss of both alleles of RB1 was an important step during leukemogenesis. © 1990.

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页码：15 / 23

页数：9

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