THE INFLUENCE OF CRYSTALLINE MORPHOLOGY AND COPOLYMER COMPOSITION ON DRUG RELEASE FROM SOLUTION CAST AND MELT-PROCESSED P(HB-HV) COPOLYMER MATRICES

被引：18

作者：

AKHTAR, S

POUTON, CW

NOTARIANNI, LJ

机构：

[1] School of Pharmacy and Pharmacology, University of Bath, Bath

来源：

JOURNAL OF CONTROLLED RELEASE | 1991年 / 17卷 / 03期

关键词：

POLYHYDROXYBUTYRATE; POLYHYDROXYVALERATE; CRYSTALLINE MORPHOLOGY; DRUG RELEASE; BIODEGRADABLE; POLYHYDROXYALKANOATES;

D O I：

10.1016/0168-3659(91)90141-Y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Crystalline poly-D(-)-3-hydroxybutyrate (PHB) and its copolymers with poly-3-hydroxyvalerate [P(HB-HV)] are biodegradable polyhydroxyalkanoates with potential application in controlled drug delivery systems. Matrices of PHB and P(HB-HV) copolymers containing a model drug, methyl red, were prepared by solvent casting and melt-processing. Drug release from P(HB-HV) copolymer matrices produced by any given fabrication technique was dependent on copolymer composition. Progressively faster rates of drug release were obtained on increasing HV content. This could be explained by the different crystallization behaviour of P(HB-HV) copolymers. Evidence from polarized light microscopy of copolymer spherulites suggests that copolymer films with increasing HV content exhibit morphologies with decreasing abilities to entrap the model drug.

引用

页码：225 / 233

页数：9

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