HEREDITARY SENSORY NEUROPATHIES

Hereditary sensory neuropathies have not shared in the major advances that have taken place in the molecular genetics of the hereditary demyelinating motor and sensory neuropathies. Thus far, classification depends upon their mode of inheritance and clinical features. The delineation of the various clinical syndromes is still not complete. This is a necessary preliminary to establishing the genetic basis of these neuropathies. The hereditary sensory neuropathies can be accordingly grouped into those with predominantly sensory and some associated autonomic features and those in which a sensory neuropathy is part of a spinocerebellar degeneration or other multisystem degeneration.