SALVAGE TRIAL OF TRIMETREXATE-LEUCOVORIN FOR THE TREATMENT OF CEREBRAL TOXOPLASMOSIS IN PATIENTS WITH AIDS

被引：33

作者：

MASUR, H ^{[1
]}

POLIS, MA ^{[1
]}

TUAZON, CU ^{[1
]}

OGATAARAKAKI, D ^{[1
]}

KOVACS, JA ^{[1
]}

KATZ, D ^{[1
]}

HILT, D ^{[1
]}

SIMMONS, T ^{[1
]}

FEUERSTEIN, I ^{[1
]}

LUNDGREN, B ^{[1
]}

LANE, HC ^{[1
]}

CHABNER, BA ^{[1
]}

ALLEGRA, CJ ^{[1
]}

机构：

[1] GEORGETOWN UNIV,WASHINGTON,DC 20057

来源：

JOURNAL OF INFECTIOUS DISEASES | 1993年 / 167卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1093/infdis/167.6.1422

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The clinical efficacy of trimetrexate, a dihydrofolate reductase inhibitor with potent in vitro antitoxoplasma activity, was assessed in 9 sulfonamide-intolerant patients with AIDS and biopsy-proven cerebral toxoplasmosis. The 9 patients were treated for 28-149 days with trimetrexate (30-280 mg/m2/day) plus leucovorin (20-90 mg/m2 every 6 h). Radiographic responses were documented in 8 patients, and clinical responses in 5 patients. Despite continued therapy, all patients deteriorated clinically and radiographically within 13-109 days of their initial improvement. Trimetrexate at very high doses for extended periods was not associated with serious toxicity. Trimetrexate alone had dramatic but transient activity in sulfonamide-intolerant patients and thus is not adequate as single-agent therapy for AIDS-associated toxoplasmosis.

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收藏

页码：1422 / 1426

页数：5

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