CARDIOVASCULAR EFFECTS OF CARBAMAZEPINE TOXICITY

被引：37

作者：

APFELBAUM, JD ^{[1
]}

CARAVATI, EM ^{[1
]}

KERNS, WP ^{[1
]}

BOSSART, PJ ^{[1
]}

LARSEN, G ^{[1
]}

机构：

[1] UNIV UTAH,HLTH SCI CTR,DIV EMERGENCY MED,SALT LAKE CITY,UT 84132

来源：

ANNALS OF EMERGENCY MEDICINE | 1995年 / 25卷 / 05期

关键词：

D O I：

10.1016/S0196-0644(95)70176-1

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Study objective: To evaluate the cardiovascular effects of carbamazepine in patients presenting to the emergency department. Design: A retrospective case series from February 1, 1985, to July 30, 1993. Setting: Six urban EDs. Participants: Seventy-two adult and pediatric patients with serum carbamazepine concentrations greater than 12 mu g/mL and concurrent 12-lead ECGs. Results: The mean carbamazepine level was 24 mu g/mL (range, 12.6 to 55 mu g/mL). Minor ECG abnormalities were noted but no clinically significant arrhythmias were found. No correlation was found between carbamazepine concentration and heart rate or PR, QRS, or corrected QT intervals. Four adult patients had transient hypotension. Conclusion: Clinically significant cardiovascular toxicity occurs rarely in patients with toxic carbamazepine concentrations. ECG findings do not correlate with serum carbamazepine concentration.

引用

页码：631 / 635

页数：5

共 20 条

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