CONTROL OF THE INTERFERON-INDUCED 68-KILODALTON PROTEIN-KINASE BY THE HIV-1 TAT GENE-PRODUCT

被引：150

作者：

ROY, S

KATZE, MG

PARKIN, NT

EDERY, I

HOVANESSIAN, AG

SONENBERG, N

机构：

[1] UNIV WASHINGTON,SCH MED,REG PRIMATE RES CTR,DEPT MICROBIOL,SEATTLE,WA 98195

[2] INST PASTEUR,UNITE ONCOL VIRALE,F-75724 PARIS,FRANCE

[3] MCGILL UNIV,MCGILL CANC CTR,MONTREAL H3G 1Y6,QUEBEC,CANADA

来源：

SCIENCE | 1990年 / 247卷 / 4947期

关键词：

D O I：

10.1126/science.2180064

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The tat-responsive region (TAR) of the human immunodeficiency virus-1 (HIV-1) exhibits a trans-inhibitory effect on translation in vitro by activating the interferon-induced 68-kilodalton protein kinase (p68 kinase). Productive infection by HIV-1 was shown to result in a significant decrease in the amount of cellular p68 kinase. The steady-state amount of p68 kinase was also reduced in interferon-treated HeLa cell lines stably expressing tat, as compared to the amount of the kinase in interferon-treated control HeLa cells. Thus, the potential translational inhibitory effects of the TAR RNA region mediated by activation of p68 kinase may be downregulated by tat during productive HIV-1 infection.

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页码：1216 / 1219

页数：4

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