HUMAN ERYTHROCYTE SUPEROXIDE-DISMUTASE IN ADULTS, NEONATES, AND NORMAL, HYPOXEMIC, ANEMIC, AND CHROMOSOMALLY ABNORMAL FETUSES

被引：17

作者：

ALIAKBAR, S

BROWN, PR

BIDWELL, D

NICOLAIDES, KH

机构：

[1] UNIV LONDON KINGS COLL,DEPT BIOCHEM,3 SEB,LONDON WC2R 2LS,ENGLAND

[2] UNIV LONDON KINGS COLL HOSP,HARRIS BIRTHRIGHT RES CTR FETAL MED,DEPT OBSTET & GYNAECOL,LONDON SE5 8RX,ENGLAND

[3] ZOOL SOC LONDON,NUFFIELD LAB COMPARAT MED,LONDON NW1 4RY,ENGLAND

来源：

CLINICAL BIOCHEMISTRY | 1993年 / 26卷 / 02期

关键词：

ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE; HYPOXEMIA; NEONATE; SMALL-FOR-GESTATIONAL-AGE FETUS; SUPEROXIDE DISMUTASE; DOWN SYNDROME;

D O I：

10.1016/0009-9120(93)90037-7

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

An enzyme-linked immunosorbent method is described for the assay of human erythrocyte superoxide dismutase (SOD). The method was specific and precise as well as simple, economical, and reliable. The mean levels of adult SOD with SD were 652 +/- 122 mg/kg hemoglobin (Hb) for males and 635 +/- 100 mg/kg Hb for females. In neonates the levels were 528 +/- 92 mg/kg Hb. Normal fetal levels at 20-36 weeks gestation were 421 +/- 90 mg/kg Hb. Mean SOD levels in hypoxemic growth-retarded fetuses and in anemic fetuses from red cell iso-immunised pregnancies (before their first intrauterine blood transfusion) were the same as those in normal fetuses. However, in a case of trisomy 21 the fetal level of SOD was significantly increased.

引用

页码：109 / 115

页数：7

共 40 条

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