MONTE-CARLO MODELING OF AEROSOL DEPOSITION IN HUMAN LUNGS .3. COMPARISON WITH EXPERIMENTAL-DATA

The Monte Carlo code IDEAL-2 described in Part I [Koblinger and Hofmann, 1990, J. Aerosol Sci. 21, 661-674] has been used to compute total and regional deposition of inhaled aerosols over a wide range of particle diameters. In the present paper, the stochastic lung model has been supplemented by specified oro- and nasopharyngeal regions. Theoretical predictions are compared to the extensive set of experimental data of Heyder et al. [1986, J. Aerosol Sci. 17,811-825] on total and regional, i.e. extrathoracic, tracheobronchial and alveolar (acinar) deposition for a variety of breathing patterns. To take account of the large individual variations observed in all measurements, intersubject variability has been modeled by scaling up and down the linear dimensions of the lung, while preserving its internal structure.