MORTALITY FROM MELANOMA IN MIGRANTS TO AUSTRALIA - VARIATION BY AGE AT ARRIVAL AND DURATION OF STAY

被引:126
作者
KHLAT, M
VAIL, A
PARKIN, M
GREEN, A
机构
[1] INT AGCY RES CANC, LYON, FRANCE
[2] UK TRANSPLANT SERV, BRISTOL, ENGLAND
关键词
MELANOMA; MIGRANTS; MORTALITY;
D O I
10.1093/oxfordjournals.aje.a116210
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
All death records in Australia during the period 1964-1985 were analyzed to compare mortality from melanoma in immigrants and Australian-born individuals, and to investigate changes in risk in the immigrants according to their duration of stay and age at arrival. About 450,000 deaths were from cancer, and risks of melanoma were estimated by logistic regression relative to those of the Australian-born, with deaths from other cancers used as controls. Estimates were adjusted for age at death, time period, birth cohort, and state of registration of death in Australia. Region of birth was defined as New Zealand, other Oceania, England, Ireland/Scotland/Wales (including Northern Ireland and the Republic of Ireland), Central Europe, Eastern Europe, Southern Europe, Western Asia, or Eastern Asia, bearing in mind that many migrants born in Asia were of European descent. Overall, migrants from outside Oceania were at lower risk than the Australian-born, and the lowest risks in males were in Southern Europeans and Eastern Asians, reflecting the protective effect of a darker complexion. Risk of melanoma was related both to duration of stay in Australia and to age at arrival; although their relative importance cannot be measured, the patterns of change suggested that childhood migration may be more important in determining risk than number of years in Australia. The authors believe this study to be based on the largest data set ever used in migrant studies, and note that the previously found differences in melanoma risk between immigrants and Australian-born remained after adjustment for major temporal and geographic confounders. The results confirm the importance of the interaction between environmental and genetic risk factors in the etiology of melanoma.
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收藏
页码:1103 / 1113
页数:11
相关论文
共 30 条
[1]   EPIDEMIOLOGY OF MALIGNANT-MELANOMA - INTERMITTENT OR TOTAL ACCUMULATED EXPOSURE TO THE SUN [J].
ARMSTRONG, BK .
JOURNAL OF DERMATOLOGIC SURGERY AND ONCOLOGY, 1988, 14 (08) :835-849
[2]  
ARMSTRONG BK, 1983, MORTALITY CANCER MIG
[3]  
ARMSTRONG BK, 1982, TRENDS CANCER INCIDE, P399
[4]  
BAKER RJ, 1978, GLIM SYSTEM
[5]  
Breslow NE, 1987, STAT METHODS CANC RE, V1
[6]   MODELS FOR TEMPORAL VARIATION IN CANCER RATES .1. AGE PERIOD AND AGE COHORT MODELS [J].
CLAYTON, D ;
SCHIFFLERS, E .
STATISTICS IN MEDICINE, 1987, 6 (04) :449-467
[7]   MODELS FOR TEMPORAL VARIATION IN CANCER RATES .2. AGE PERIOD COHORT MODELS [J].
CLAYTON, D ;
SCHIFFLERS, E .
STATISTICS IN MEDICINE, 1987, 6 (04) :469-481
[8]   MALIGNANT-MELANOMA - THE AUSTRALIAN CONTRIBUTION [J].
DAVIS, NC .
AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY, 1988, 58 (08) :605-617
[9]   MORTALITY FROM MALIGNANT-MELANOMA IN AUSTRALIA - EFFECTS DUE TO COUNTRY OF BIRTH [J].
DOBSON, AJ ;
LEEDER, SR .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1982, 11 (03) :207-211
[10]   RELATIONSHIP OF MELANOMA AND OTHER SKIN CANCER MORTALITY TO LATITUDE AND ULTRAVIOLET RADIATION IN UNITED-STATES AND CANADA [J].
ELWOOD, JM ;
LEE, JAH ;
WALTER, SD ;
MO, T ;
GREEN, AES .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1974, 3 (04) :325-332