BACTERIAL IMMUNITY AND IMMUNOGENESIS OF NORMAL HUMAN SALIVARY IGA AND SERUM IGG2 ANTIPHOSPHOLIPID AUTOANTIBODY - A LINK

被引：10

作者：

CHENG, HM ^{[1
]}

SAM, CK ^{[1
]}

机构：

[1] UNIV MALAYA,FAC MED,DEPT OTORHINOLARYNGOL,KUALA LUMPUR,MALAYSIA

来源：

IMMUNOLOGY LETTERS | 1990年 / 26卷 / 01期

关键词：

Antiphospholipid autoantibody; Bacterial immunity; Immunoglobulin A; Immunoglobulin G[!sub]2[!/sub;

D O I：

10.1016/0165-2478(90)90168-P

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The anti-phospholipid antibody (aPL) in 26 heat-inactivated normal human sera (NHS) was tested for IgG subclass in ELISA. The specific antibody in NHS included all four IgG antibody subclasses, as well as IgA. The incidence of IgG subclasses ranged from 50% (13/26) for IgG1 to 92% (24/26) for IgG2. Specific IgA anti-phospholipid antibody (aPL) was detected by ELISA in 38% (28/73) of normal human saliva. The salivary IgA aPL bound preferentially to anionic phospholipids including cardiolipin, phosphatidylserine and phosphatidic acid but not to phosphatidylcholine or sphingomyelin. Unlike aPL in normal human sera, aPL in saliva was predominantly not associated with the previously described heat-labile inhibitor of aPL. This may indicate a role of salivary IgA aPL in local immunity by binding to cross-reactive bacterial cell surface components including phospholipids. © 1990.

引用

页码：7 / 10

页数：4

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