CHARACTERIZATION OF THE PRINCIPAL METABOLITE OF QUININE IN HUMAN URINE BY H-1-NMR SPECTROSCOPY

被引：9

作者：

BOLAJI, OO ^{[1
]}

BABALOLA, CP ^{[1
]}

DIXON, PAF ^{[1
]}

机构：

[1] OBAFEMI AWOLOWO UNIV,DEPT PHARMACOL,IFE,NIGERIA

来源：

XENOBIOTICA | 1991年 / 21卷 / 04期

关键词：

D O I：

10.3109/00498259109039484

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The major metabolite of quinine in human urine, which is also the sole metabolite in human plasma and saliva, has been identified and characterized by chemical ionization mass spectrometry and H-1-n.m.r. spectrometry. 2. The mass spectrum showed that an oxygen atom is incorporated in the quinuclidine nucleus, and the exact position of the oxidation was established from the n.m.r. spectrum to be at the C-3 position.

引用

页码：447 / 450

页数：4

共 7 条

[1]

ANYABUIKE CP, 1990, IN PRESS W AFRICAN J

[2] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION AND ISOLATION OF QUINIDINE AND QUININE METABOLITES IN RAT URINE [J].