SURFACE-ANTIGEN VARIABILITY AND VARIATION IN GIARDIA-LAMBLIA

被引：112

作者：

NASH, T

机构：

[1] Theodore Nash is at the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, Building 4

来源：

PARASITOLOGY TODAY | 1992年 / 8卷 / 07期

关键词：

D O I：

10.1016/0169-4758(92)90119-M

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Recent studies show that Giardia isolates are heterogeneous but fall into at least three groups as determined by a number of complementary techniques. Giardia undergoes surface antigenic variation, both in vitro, and in humans and other animal model infections. Many of the characteristics of antigenic variation and the proteins involved, called variant-specific surface proteins (VSPs), are unique. The sequences of five VSPs reveal a family of cysteine-rich proteins. Here Theodore Nash reviews the relationship between antigenic variation and Giardia heterogeneity.

引用

页码：229 / 234

页数：6

共 37 条

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