EFFECTS OF CALCIUM-CHANNEL AND H-1-RECEPTOR BLOCKERS ON THE RESPONSES OF SLOWLY ADAPTING PULMONARY STRETCH RECEPTORS TO HISTAMINE IN VAGOTOMIZED RABBITS

We studied the effects of calcium channel antagonists (verapamil and nifedipine) and H-1-receptor blockers (mequitazine) on changes in the slowly adapting pulmonary stretch receptors (SARs) located below the carina in response to right atrial injections of histamine (60 and 80 mug/kg) in anesthetized artificially ventilated rabbits with bilateral vagotomy. After histamine was injected into the right atrium, the SARs became more active during expiration but decreased their activity during inspiration. These changes were more pronounced by increasing the dosage of histamine. However, administration of histamine had no significant effect on tracheal pressure (P(T)). Verapamil treatment (1 mg/kg) did not alter the SAR response to histamine, whereas the responses of SARs to histamine at different dosages were significantly diminished by treatment with nifedipine (1 mg/kg). Mequitazine (1 mg/kg), a potent H-1-receptor blocker, blocked completely all the responses of SAR activity to histamine. These results suggest that the effect of histamine 60-80 mug/kg on SAR activity is mediated by the activation of H-1-receptors of the peripheral airway smooth muscle and that this activation, at least in part, involves the opening of calcium channels of the airway smooth muscle.