ANTI-HEPATITIS-A VIRUS-ANTIBODY RESPONSE ELICITED IN MICE BY DIFFERENT FORMS OF A SYNTHETIC VP1 PEPTIDE

被引：16

作者：

HARO, I

PINTO, RM

GONZALEZDANKAART, JF

PEREZ, JA

REIG, F

BOSCH, A

机构：

[1] UNIV BARCELONA, FAC BIOL, DEPT MICROBIOL, E-08028 BARCELONA, SPAIN

[2] CSIC, CID, DEPT PEPTIDES, E-08034 BARCELONA, SPAIN

来源：

MICROBIOLOGY AND IMMUNOLOGY | 1995年 / 39卷 / 07期

关键词：

HEPATITIS A; SYNTHETIC PEPTIDES; LIPOSOMES; MULTIPLE ANTIGEN PEPTIDE SYSTEM;

D O I：

10.1111/j.1348-0421.1995.tb02232.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Peptide VP1 (11-25) of the capsid of hepatitis A virus was synthesized by the Fmoc-polyamide solid phase method, and administered to mice in different forms: (1) free, (2) encapsulated in multilamellar liposomes, (3) coupled to keyhole limpet hemocyanin (KHL), acid (4) incorporated into a tetrameric branched lysine core. The highest anti-VP1 peptide responses were generated by synthetic peptides entrapped into liposomes and coupled to KLH. No anti-HAV response was generated with the free peptide, while all the other forms induced both anti-HAV and HAV-neutralizing antibodies. Maximum neutralization indices were observed in ascites from mice treated with liposome-entrapped acid KLH peptides.

引用

页码：485 / 490

页数：6

共 32 条

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