NONSTEROIDAL ANTIINFLAMMATORY DRUGS AND GASTROINTESTINAL-DISEASE - PATHOPHYSIOLOGY, TREATMENT AND PREVENTION

被引：19

作者：

BJORKMAN, DJ

KIMMEY, MB

机构：

[1] University of Utah, School of Medicine, Salt Lake City, UT

[2] University of Washington Medical Center, Seattle, WA

来源：

DIGESTIVE DISEASES | 1995年 / 13卷 / 02期

关键词：

NONSTEROIDAL; ANTIINFLAMMATORY DRUGS; GASTROINTESTINAL; COMPLICATIONS; GASTRIC ULCER; DUODENAL ULCER; GASTROINTESTINAL BLEEDING;

D O I：

10.1159/000171493

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a common cause of gastrointestinal ulceration. Chronic NSAID use increases the risk of ulcer bleeding or perforation 3- to 4-fold. NSAID-induced injury results from both local effects and systemic prostaglandin inhibition. New evidence suggests that the systemic effects on prostaglandin production may vary between NSAIDs. The majority of NSAID-induced ulcers are asymptomatic. They may be treated by discontinuing the NSAID and using standard ulcer therapy. Patients taking NSAIDs who are at a high risk for a GI complication should also receive therapy to decrease their risk for ulceration. In this review the epidemiology, pathogenesis, risks, treatment and prophylaxis of NSAID-induced gastrointestinal complications are discussed.

引用

页码：119 / 129

页数：11

共 81 条

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