EFFECTS OF A GONADOTROPIN-RELEASING-HORMONE AGONIST ON OOCYTE MATURATION, FERTILIZATION, AND EMBRYONAL DEVELOPMENT IN MICE

被引：17

作者：

YANG, BC ^{[1
]}

UEMURA, T ^{[1
]}

MINAGUCHI, H ^{[1
]}

机构：

[1] YOKOHAMA CITY UNIV,SCH MED,DEPT OBSTET & GYNECOL,KANAZAWA KU,YOKOHAMA,KANAGAWA 236,JAPAN

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 1995年 / 12卷 / 10期

关键词：

GONADOTROPIN RELEASING HORMONE (GNRH) AGONIST; GNRH ANTAGONIST; OOCYTE MATURATION; IN VITRO FERTILIZATION;

D O I：

10.1007/BF02212901

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Purpose: The effects of a GnRH agonist (GnRHa) on oocyte quality were investigated by assessing the influence of GnRHa on oocytes, and fertilized oocytes were examined in vivo and in vitro. Administration of gonadotropin in conjunction with GnRHa induced a significantly gl eater degree of germinal vesicle breakdown, significantly higher rates of in vitro fertilization, and significantly faster development of the oocytes than with pregnant mare serum gonadotropin alone. Results: The hatching-success rate in the GnRHa treated hypophysectomized mice was higher than in control mice. The rate of in vitro fertilization was also higher in oocytes cultured in the presence of low doses of GnRHa and these effects were reversed by a GnRH antagonist. Conclusion: Oocytes obtained following ovarian stimulation with GnRHa were of higher quality than control oocytes, and the efficacy of GnRHa may be due in part to its direct action on the ovary.

引用

页码：728 / 732

页数：5

共 19 条

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