ISOLATION AND COMPLETE SEQUENCE OF CBR, A GENE ENCODING A PUTATIVE CYTOCHROME-B REDUCTASE IN SACCHAROMYCES-CEREVISIAE

被引：16

作者：

CSUKAI, M ^{[1
]}

MURRAY, M ^{[1
]}

ORR, E ^{[1
]}

机构：

[1] UNIV LEICESTER, DEPT GENET, LEICESTER LE1 7RH, ENGLAND

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1994年 / 219卷 / 1-2期

基金：

英国惠康基金;

关键词：

D O I：

10.1111/j.1432-1033.1994.tb19957.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated and characterised a novel yeast gene, CBR (cytochrome b reductase), encoding a 35-kDa yeast novobiocin-binding protein. The predicted protein sequence of CBR displays considerable similarity to both plant nitrate reductases and mammalian cytochrome b(5) reductases indicating that it is a putative member of the flavoprotein pyridine-nucleotide-cytochrome-reductase family. Disruption of CBR is not lethal under various growth conditions, suggesting the presence of some functional overlap with other reductases, possibly with the cytochrome P-450 reductase.

引用

页码：441 / 448

页数：8

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