BRAIN UPTAKE OF TRACE-METALS, ZINC AND MANGANESE, IN RATS

被引：91

作者：

TAKEDA, A ^{[1
]}

AKIYAMA, T ^{[1
]}

SAWASHITA, J ^{[1
]}

OKADA, S ^{[1
]}

机构：

[1] SHIZUOKA COLL PHARMACEUT SCI, SCH PHARMACEUT SCI, DEPT RADIOBIOCHEM, 52-1 YADA, SHIZUOKA 422, JAPAN

来源：

BRAIN RESEARCH | 1994年 / 640卷 / 1-2期

关键词：

BRAIN; HIPPOCAMPUS; CHOROID PLEXUS; BLOOD BRAIN BARRIER; ZINC; MANGANESE; ESSENTIAL TRACE METAL;

D O I：

10.1016/0006-8993(94)91891-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The brains of rats injected intravenously with (ZnCl2)-Zn-65 or (MnCl2)-Mn-54 were subjected to high resolution autoradiography. Zn-65 and Mn-54 were largely concentrated in choroid plexus 1 h after injection and then gradually decreased, with increases in other brain regions, suggesting that both metals were taken up gradually into brain mainly via cerebrospinal fluid in the choroid plexus. By 3 days after injection, relatively high level of Zn-65 was seen in the dentate gyrus and CA3 region of the hippocampus and in the cerebral cortex. The level of Mn-54 was also high in the former, while relatively low in the latter.

引用

页码：341 / 344

页数：4

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