NUCLEASE ACTIVITY OF A HYDROXAMIC ACID-DERIVATIVE IN THE PRESENCE OF VARIOUS METAL-IONS

被引：45

作者：

HASHIMOTO, S ^{[1
]}

NAKAMURA, Y ^{[1
]}

机构：

[1] SCI UNIV TOKYO,DEPT BIOL SCI & TECHNOL,NODA,CHIBA 278,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 14期

关键词：

D O I：

10.1039/c39950001413

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Phenanthridine-linked hydroxamic acid 1 effectively cleaves ColE1 DNA in the presence of transition (ferrous, ferric and vanadyl) or lanthanide(iii) (lutetium, thulium and europium) metal ions; in the presence of the former, the cleavage is inhibited by free radical scavengers, but in the latter case it is not.

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页码：1413 / 1414

页数：2

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