Manganese: a unique neuroimaging contrast agent

被引：15

作者：

Bock, Nicholas A. ^{[1
]}

Silva, Afonso C. ^{[1
]}

机构：

[1] Natl Inst Hlth, Natl Inst Neurol Disorders Stroke, Cerebral Microcirculat Unit, Funct & Mol Imaging, 10 Ctr Bldg 10,Room BD109 Bethesda, Bethesda, MD 20892 USA

来源：

FUTURE NEUROLOGY | 2007年 / 2卷 / 03期

关键词：

animal models of disease; basal ganglia; CNS; contrast agent; functional imaging; magnetic resonance imaging; neuronal tract tracer;

D O I：

10.2217/14796708.2.3.297

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Manganese is a strong magnetic resonance imaging relaxation agent with unique biological properties that make it suitable for in vivo studies of neuroachitecture, neuronal tracts and neuronal function in animals. However, in humans large doses of manganese are neurotoxic and cause damage, primarily to the basal ganglia, resulting in a form of parkinsonism termed manganism. If low doses can be safely used and detected in the human brain, manganese will provide insight into neuroanatomy, connectivity, function and neuropathology.

引用

页码：297 / 305

页数：9

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