THIOACYLATING AGENTS AS ULTIMATE INTERMEDIATES IN THE BETA-LYASE CATALYZED METABOLISM OF S-(PENTACHLORO-BUTADIENYL)-L-CYSTEINE

被引：43

作者：

DEKANT, W

BERTHOLD, K

VAMVAKAS, S

HENSCHLER, D

机构：

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1988年 / 67卷 / 1-2期

关键词：

D O I：

10.1016/0009-2797(88)90093-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：139 / 148

页数：10

共 15 条

[1] BIOACTIVATION MECHANISM OF THE CYTOTOXIC AND NEPHROTOXIC S-CONJUGATE S-(2-CHLORO-1,1,2-TRIFLUOROETHYL)-L-CYSTEINE [J].

DEKANT, W ;

LASH, LH ;

ANDERS, MW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) :7443-7447

[2]

DEKANT W, 1987, DRUG METAB DISPOS, V15, P702

[3] BACTERIAL BETA-LYASE MEDIATED CLEAVAGE AND MUTAGENICITY OF CYSTEINE CONJUGATES DERIVED FROM THE NEPHROCARCINOGENIC ALKENES TRICHLOROETHYLENE, TETRACHLOROETHYLENE AND HEXACHLOROBUTADIENE [J].

DEKANT, W ;

VAMVAKAS, S ;

BERTHOLD, K ;

SCHMIDT, S ;

WILD, D ;

HENSCHLER, D .

CHEMICO-BIOLOGICAL INTERACTIONS, 1986, 60 (01) :31-45

[4]

DEKANT W, 1988, IN PRESS XENOBIOTICA

[5] STRUCTURE ACTIVITY STUDIES OF THE NEPHROTOXIC AND MUTAGENIC ACTION OF CYSTEINE CONJUGATES OF CHLOROALKENES AND FLUOROALKENES [J].

GREEN, T ;

ODUM, J .

CHEMICO-BIOLOGICAL INTERACTIONS, 1985, 54 (01) :15-31

[6] INVIVO AND INVITRO NEPHROTOXICITY OF THE CYSTEINE CONJUGATE OF HEXACHLOROBUTADIENE [J].

JAFFE, DR ;

HASSALL, CD ;

BRENDEL, K ;

GANDOLFI, AJ .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1983, 11 (4-6) :857-867

[7] THE MECHANISM OF PENTACHLOROBUTADIENYL-GLUTATHIONE NEPHROTOXICITY STUDIED WITH ISOLATED RAT RENAL EPITHELIAL-CELLS [J].

JONES, TW ;

WALLIN, A ;

THOR, H ;

GERDES, RG ;

ORMSTAD, K ;

ORRENIUS, S .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1986, 251 (02) :504-513

[8] NON-ENZYMATIC TRANSAMINATION AND BETA-ELIMINATION OF DL-S-BENZYLCYSTEINE CATALYZED BY A POTENT PYRIDOXAL MODEL [J].

KIKUCHI, J ;

SUNAMOTO, J ;

KONDO, H .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1985, (03) :341-345

[9] THE METABOLISM AND DISPOSITION OF HEXACHLORO-1-3-BUTADIENE IN THE RAT AND ITS RELEVANCE TO NEPHROTOXICITY [J].

NASH, JA ;

KING, LJ ;

LOCK, EA ;

GREEN, T .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1984, 73 (01) :124-137

[10] EXCRETION PATTERN AND METABOLISM OF HEXACHLOROBUTADIENE IN RATS - EVIDENCE FOR METABOLIC-ACTIVATION BY CONJUGATION REACTIONS [J].

REICHERT, D ;

SCHUTZ, S ;

METZLER, M .

BIOCHEMICAL PHARMACOLOGY, 1985, 34 (04) :499-505

← 1 2 →