AUTORADIOGRAPHIC LOCALIZATION OF D1-DOPAMINE AND D2-DOPAMINE BINDING-SITES IN THE HUMAN RETINA

被引：30

作者：

DENIS, P ^{[1
]}

ELENA, PP ^{[1
]}

NORDMANN, JP ^{[1
]}

SARAUX, H ^{[1
]}

LAPALUS, P ^{[1
]}

机构：

[1] FAC MED NICE,DEPT PHARMACOL,F-06034 NICE,FRANCE

来源：

NEUROSCIENCE LETTERS | 1990年 / 116卷 / 1-2期

关键词：

Autoradiography; Dopamine receptor; Human; Human retina; [!sup]125[!/sup]I]Iodosulpride; [!sup]125[!/sup]I]SCH 23982;

D O I：

10.1016/0304-3940(90)90390-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The localization of dopamine binding sites was studied by in vitro autoradiography in the normal human retina using [125I]SCH 23982 for D1 receptor labelling and [125I]iodosulpride for D2 receptors. Results demonstrated that both types of binding sites were present in human retina. Binding of [125I]SCH 23982 to D1 dopamine receptor was blocked by 1 μM SKF 38393, SCH 23390 (D1 specific compounds) whereas bromocriptine and domperidone (D2 specific compounds) were inactive at the same concentration. On the contrary, binding of [125I]iodosulpride to D2 dopamine receptor was inhibited only by D2 drugs. Precise cellular distribution was given by microautoradiographic techniques and showed that binding sites were exclusively localized to the plexiform layers. © 1990.

引用

页码：81 / 86

页数：6

共 26 条

[1] DOPAMINE-D1 RECEPTOR IN RAT-BRAIN - A QUANTITATIVE AUTORADIOGRAPHIC STUDY WITH T-125-SCH-23982 [J].