MOLECULAR GENETIC-STUDIES OF MAJOR HISTOCOMPATIBILITY COMPLEX GENES IN CHILDREN WITH JUVENILE DERMATOMYOSITIS - INCREASED RISK ASSOCIATED WITH HLA-DQA1-0501

被引：58

作者：

REED, AM

PACHMAN, L

OBER, C

机构：

[1] NORTHWESTERN UNIV,CHILDRENS MEM HOSP,SCH MED,DIV IMMUNOL & RHEUMATOL,CHICAGO,IL 60614

[2] UNIV CHICAGO,SCH MED,MOLEC GENET LAB,CHICAGO,IL 60637

[3] NORTHWESTERN UNIV,CHILDRENS MEM HOSP,SCH MED,DEPT PEDIAT,CHICAGO,IL 60614

[4] UNIV CHICAGO,SCH MED,DEPT OBSTET & GYNECOL,CHICAGO,IL 60637

来源：

HUMAN IMMUNOLOGY | 1991年 / 32卷 / 04期

关键词：

D O I：

10.1016/0198-8859(91)90085-N

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our results indicate that JDMS is associated with the HLA-DQA1 allele DQA1*0501 on non-DR3 haplotypes in Caucasian JDMS. Furthermore, the reported of association between the C4A gene deletion and JDMS is likely due to linkage disequilibrium with HLA-DR3.

引用

页码：235 / 240

页数：6

共 28 条

[1] POLYMORPHIC DNA REGION ADJACENT TO THE 5'-END OF THE HUMAN INSULIN GENE [J].

BELL, GI ;

KARAM, JH ;

RUTTER, WJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09) :5759-5763

[2]

BENBASSAT M, 1972, AM J CLIN PATHOL, V58, P245

[3]

BOHEN A, 1975, NEW ENGL J MED, V292, P403

[4]

BOHEN A, 1975, NEW ENGL J MED, V292, P344

[5] A MOLECULAR MAP OF THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-III REGION LINKING COMPLEMENT GENES-C4, GENE-C2 AND FACTOR-B [J].

CARROLL, MC ;

CAMPBELL, RD ;

BENTLEY, DR ;

PORTER, RR .

NATURE, 1984, 307 (5948) :237-241

[6] PREVALENCE OF COXSACKIE-B VIRUS-ANTIBODIES IN PATIENTS WITH JUVENILE DERMATOMYOSITIS [J].

CHRISTENSEN, ML ;

PACHMAN, LM ;

SCHNEIDERMAN, R ;

PATEL, DC ;

FRIEDMAN, JM .

ARTHRITIS AND RHEUMATISM, 1986, 29 (11) :1365-1370

[7]

COX NJ, 1988, AM J HUM GENET, V43, P954

[8]

Erlich H.A., 1989, PCR TECHNOLOGY

[9] FAMILY STUDY OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - IMPORTANCE OF NULL ALLELES OF C4A AND C4B IN DETERMINING DISEASE SUSCEPTIBILITY [J].

FIELDER, AHL ;

WALPORT, MJ ;

BATCHELOR, JR ;

RYNES, RI ;

BLACK, CM ;

DODI, IA ;

HUGHES, GRV .

BMJ-BRITISH MEDICAL JOURNAL, 1983, 286 (6363) :425-428

[10]

FRIEDMAN JM, 1983, TISSUE ANTIGENS, V21, P45

← 1 2 3 →