FLUTAMIDE-INDUCED METHEMOGLOBINEMIA

被引：11

作者：

SCHOTT, AM ^{[1
]}

VIAL, T ^{[1
]}

GOZZO, I ^{[1
]}

CHAREYRE, S ^{[1
]}

DELMAS, PD ^{[1
]}

机构：

[1] E HERRIOT HOSP,POST MARKETING DRUG SURVEILLANCE & POISON CONTROL CTR,DEPT RHEUMATOL,F-69003 LYONS,FRANCE

来源：

DICP-THE ANNALS OF PHARMACOTHERAPY | 1991年 / 25卷 / 06期

关键词：

D O I：

10.1177/106002809102500606

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The authors report a case of clinical methemoglobinemia occurring one year after a patient began receiving flutamide 750 mg/d for prostate cancer with bone metastasis. The patient presented with severe cyanosis involving his lips and proximal extremities and moderate dyspnea. Methemoglobinemia was 16.2 percent of the total hemoglobin and intravenous ascorbic acid was administered. Clinical examination and laboratory analysis revealed no other cause. There was no biochemical evidence of congenital methemoglobinemia and no other regular drug use or chemical exposure was found. Moreover, clinical improvement and normalization of the methemoglobin level after the drug was discontinued is highly suggestive of flutamide-induced methemoglobinemia. Due to its chemical structure derived from anilide, flutamide may be considered as a potential methemoglobin-inducing agent.

引用

页码：600 / 601

页数：2

共 5 条

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BROGDEN, RN
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[3] HAEFLIGER JM, 1985, MED HYG, V43, P3445
[4] DRUG-INDUCED AND CHEMICAL-INDUCED METHEMOGLOBINEMIA - CLINICAL-FEATURES AND MANAGEMENT
HALL, AH
KULIG, KW
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[J]. MEDICAL TOXICOLOGY AND ADVERSE DRUG EXPERIENCE, 1986, 1 (04): : 253 - 260
[5] KEATING MA, 1986, J UROLOGY, V135, pA203

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