INFLAMMATORY PROCESSES IN ASTHMA

被引:28
作者
BOUSQUET, J
CHANEZ, P
CAMPBELL, AM
LACOSTE, JY
POSTON, R
ENANDER, I
GODARD, P
MICHEL, FB
机构
[1] PHARMACIA DIAGNOST AB,UPPSALA,SWEDEN
[2] GUYS HOSP,DEPT PATHOL,LONDON SE1 9RT,ENGLAND
来源
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1991年 / 94卷 / 1-4期
关键词
D O I
10.1159/000235367
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Bronchial inflammation is a characteristic of asthma, but, although postmortem and rare bronchoscopic studies had been performed, it is only after 1980 that many experiments were done. Electron microscopy, immunohistochemistry and molecular biology have enhanced our knowledge. As bronchial biopsies and bronchoalveolar lavage present drawbacks, it is favorable to combine both to obtain the best insights into inflammation. The epithelium is rarely intact in asthmatic patients, the cells being both 'fragile' and activated. Eosinophil inflammation is highly important and likely involved in the damage of the epithelium and submucosa. Airway macrophages and monocytes are present in greater amounts and are activated in the bronchi, and they are certainly involved in the pathogenesis of asthma. Mast cells are activated and some emphasis has been put on lymphocytes. Therefore, asthma appears to be a desquamative bronchitis with mixed cell infiltrate.
引用
收藏
页码:227 / 232
页数:6
相关论文
共 34 条
[2]  
ANDERSON ND, 1976, IMMUNOLOGY, V31, P455
[3]   CELLULAR EVENTS IN THE BRONCHI IN MILD ASTHMA AND AFTER BRONCHIAL PROVOCATION [J].
BEASLEY, R ;
ROCHE, WR ;
ROBERTS, JA ;
HOLGATE, ST .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 139 (03) :806-817
[4]   EOSINOPHILIC INFLAMMATION IN ASTHMA [J].
BOUSQUET, J ;
CHANEZ, P ;
LACOSTE, JY ;
BARNEON, G ;
GHAVANIAN, N ;
ENANDER, I ;
VENGE, P ;
AHLSTEDT, S ;
SIMONYLAFONTAINE, J ;
GODARD, P ;
MICHEL, FB .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (15) :1033-1039
[5]  
BOUSQUET J, IN PRESS J ALLERGY C
[6]  
CAPRON A, 1989, PROG ALLERGY CLIN IM, P23
[7]  
CARROLLMP, 1989, HUMAN MONOCYTES, P493
[8]  
CHANEZ P, 1989, American Review of Respiratory Disease, V139, pA482
[9]  
CHANEZ P, IN PRESS AM REV RESP
[10]   ENHANCED ALVEOLAR CELL LUMINOL-DEPENDENT CHEMILUMINESCENCE IN ASTHMA [J].
CLUZEL, M ;
DAMON, M ;
CHANEZ, P ;
BOUSQUET, J ;
DEPAULET, AC ;
MICHEL, FB ;
GODARD, P .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1987, 80 (02) :195-201