CHROMOSOME-ABNORMALITIES IN LYMPHOCYTES AND FIBROBLASTS OF SUBJECTS WITH MULTIPLE ENDOCRINE NEOPLASIA TYPE-1

被引：42

作者：

SCAPPATICCI, S ^{[1
]}

MARASCHIO, P ^{[1
]}

DELCIOTTO, N ^{[1
]}

FOSSATI, GS ^{[1
]}

ZONTA, A ^{[1
]}

FRACCARO, M ^{[1
]}

机构：

[1] UNIV PAVIA,DIPARTMENTO CHIRURG,I-27100 PAVIA,ITALY

来源：

CANCER GENETICS AND CYTOGENETICS | 1991年 / 52卷 / 01期

关键词：

D O I：

10.1016/0165-4608(91)90057-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A consistent degree of chromosome instability was found in cultured lymphocytes and in fibroblasts derived from skin biopsies of three patients with multiple endocrine neoplasia type 1 (MEN1). In both tissues, there was a significant increase in chromosomal breakage. Dicentrics and tricentrics, rings, translocations, deletions, acentric fragments, and presumptive double minutes were the most frequent abnormalities in lymphocytes. The fibroblasts of two patients had large clones consisting of trisomy 7 and trisomy 18 cells, respectively.

引用

页码：85 / 92

页数：8

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