HOX GENE ACTIVATION BY RETINOIC ACID

被引：204

作者：

BONCINELLI, E ^{[1
]}

SIMEONE, A ^{[1
]}

ACAMPORA, D ^{[1
]}

MAVILIO, F ^{[1
]}

机构：

[1] IST SCI HS RAFFAELE,I-20132 MILAN,ITALY

来源：

TRENDS IN GENETICS | 1991年 / 7卷 / 10期

关键词：

D O I：

10.1016/0168-9525(91)90423-N

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Vertebrate homeobox genes of the Hox family are, like Drosophila homeotic genes, organized in gene clusters and show a strict correspondence, or collinearity, between the order of the genes (3' to 5') within the chromosomal cluster and that of their expression domains (anterior to posterior) in the embryo. Recent data obtained from embryonal carcinoma cells induced to differentiate by retinoic acid cast some light on the molecular mechanisms underlying the collinear expression of the Hox genes.

引用

页码：329 / 334

页数：6

共 38 条

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[10] EVX2, A HUMAN HOMEOBOX GENE HOMOLOGOUS TO THE EVEN-SKIPPED SEGMENTATION GENE, IS LOCALIZED AT THE 5' END OF HOX4 LOCUS ON CHROMOSOME-2
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