DIFFERENTIAL EFFICACIES OF DOPAMINE D1 RECEPTOR AGONISTS FOR STIMULATING ADENYLYL-CYCLASE IN SQUIRREL-MONKEY AND RAT

被引：72

作者：

IZENWASSER, S

KATZ, JL

机构：

[1] Psychobiology Section, NIDA Addiction Research Center, Baltimore, MD

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1993年 / 246卷 / 01期

关键词：

DOPAMINE D1 RECEPTOR; ADENYLYL CYCLASE;

D O I：

10.1016/0922-4106(93)90007-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adenylyl cyclase activity was stimulated by dopamine to approximately 200% over basal activity in both squirrel monkey caudate and rat caudate-putamen. The selective dopamine D1 receptor agonists SKF 82958, A68930, dihydrexidine, CY 208-243, and SKF 75670 each produced similar maximal stimulation across the two species. SKF 38393, SKF 81297, and 6-Br-APB, however, each had higher efficacy in rat than in monkey. These results suggest differences in dopamine D1 receptors in the two species.

引用

页码：39 / 44

页数：6

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