INHIBITORY EFFECTS OF PROSTACYCLIN ANALOG, TFC-132, ON AORTIC NEOINTIMAL THICKENING IN-VIVO AND SMOOTH-MUSCLE CELL-PROLIFERATION IN-VITRO

被引：20

作者：

ASADA, Y ^{[1
]}

KISANUKI, A ^{[1
]}

HATAKEYAMA, K ^{[1
]}

TAKAHAMA, S ^{[1
]}

KOYAMA, T ^{[1
]}

KUROZUMI, S ^{[1
]}

SUMIYOSHI, A ^{[1
]}

机构：

[1] TEIJIN INST BIOMED RES,HINO,TOKYO 191,JAPAN

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1994年 / 51卷 / 04期

关键词：

D O I：

10.1016/0952-3278(94)90187-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effects of a new prostacyclin analogue, TFC-132, on neointimal thickening following intimal mechanical injury and on the proliferation of cultured aortic smooth muscle cells (SMCs) were studied. The intimal injury was induced by indwelling of polyethylene tubing for 24 h in the rabbit aorta. Rabbits mere killed 10 days after drawing out the tubing. TFC-132 (0.6 mg/kg or 1.2 mg/kg) was given orally at 8-h intervals through the experiment. The serum concentrations of the analogue rose significantly 1 and 2h after administration. The mean intimal thickening in the TFC-132 treated groups was significantly thinner than in the control one. Human aortic SMCs were cultured and H-3-thymidine incorporation into DNA (DNA synthesis) was measured at the varying concentrations of TFC-132. The analogue inhibited DNA synthesis of cultured SMCs at 10(-6) and 10(-5) M. These data indicate that a nem prostacyclin analogue, TFC-132, has an inhibitory effect on the neointimal thickening after intimal injury and on the aortic SMC proliferation.

引用

页码：245 / 248

页数：4

共 16 条

[1] STABLE ANALOGS OF PROSTACYCLIN AND THROMBOXANE-A2 DISPLAY CONTRADICTORY INFLUENCES ON ATHEROSCLEROTIC PROPERTIES OF CELLS CULTURED FROM HUMAN AORTA - THE EFFECT OF CALCIUM-ANTAGONISTS [J].