INVIVO MEASUREMENT OF THE OPTICAL INTERACTION COEFFICIENTS OF HUMAN TUMORS AT 630 NM

被引:39
作者
DRIVER, I [1 ]
LOWDELL, CP [1 ]
ASH, DV [1 ]
机构
[1] UNIV LEEDS,DEPT RADIOTHERAPY,LEEDS LS1 3EX,W YORKSHIRE,ENGLAND
关键词
D O I
10.1088/0031-9155/36/6/008
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The light distribution within a treatment volume is determined by the source geometry (e.g. superficial or interstitial illumination) and the optical interaction coefficients of the irradiated tissue. We have measured the energy fluence rate at various points within tumours undergoing irradiation with 630 nm light for photodynamic therapy for several source geometries. The relative positions of source and detector fibres were determined using CT scanning techniques. The results of the measurements were then applied to solutions of the diffusion theory which allowed the determination of the absorption coefficient (SIGMA-a = 30.5 +/- 16 m-1), the reduced scattering coefficient (SIGMA-s' = 941 +/- 735 m-1), the effective attenuation coefficient (SIGMA-eff = 261 +/- 49 m-1) and the build-up coefficient which relates surface irradiance to the energy fluence rate at depth (k = 1.6 +/- 0.6). Knowledge of these coefficients allows the transmission of light through tissue to be predicted and hence the optical dosimetry of subsequent treatments to be planned more effectively.
引用
收藏
页码:805 / 813
页数:9
相关论文
共 11 条
[1]   A SIMPLE PROJECTOR FOR SUPERFICIAL LASER PHOTODYNAMIC THERAPY [J].
ALLEN, V ;
ESSEX, TJH ;
MCKENZIE, AL .
PHYSICS IN MEDICINE AND BIOLOGY, 1989, 34 (07) :927-930
[2]  
FEATHER J W, 1990, Lasers in Medical Science, V5, P345, DOI 10.1007/BF02032590
[3]  
Feather J. W., 1989, LASER MED SCI, V4, P229
[4]   EXTINCTION AND ABSORPTION-COEFFICIENTS AND SCATTERING PHASE FUNCTIONS OF HUMAN-TISSUES INVITRO [J].
MARCHESINI, R ;
BERTONI, A ;
ANDREOLA, S ;
MELLONI, E ;
SICHIROLLO, AE .
APPLIED OPTICS, 1989, 28 (12) :2318-2324
[5]  
MARIJNISSEN J P A, 1987, Lasers in Medical Science, V2, P235, DOI 10.1007/BF02594166
[6]   CALCULATING THE RESPONSE OF ISOTROPIC LIGHT DOSIMETRY PROBES AS A FUNCTION OF THE TISSUE REFRACTIVE-INDEX [J].
STAR, WM ;
MARIJNISSEN, JPA .
APPLIED OPTICS, 1989, 28 (12) :2288-2291
[7]  
SVAASAND LO, 1984, PORPHYRIN LOCALIZATI, P91
[8]  
WILSON B C, 1986, Lasers in Medical Science, V1, P235, DOI 10.1007/BF02032418
[9]   INSTRUMENTATION AND LIGHT DOSIMETRY FOR INTRAOPERATIVE PHOTODYNAMIC THERAPY (PDT) OF MALIGNANT BRAIN-TUMORS [J].
WILSON, BC ;
MULLER, PJ ;
YANCH, JC .
PHYSICS IN MEDICINE AND BIOLOGY, 1986, 31 (02) :125-133
[10]   INVIVO AND POST-MORTEM MEASUREMENTS OF THE ATTENUATION SPECTRA OF LIGHT IN MAMMALIAN-TISSUES [J].
WILSON, BC ;
JEEVES, WP ;
LOWE, DM .
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1985, 42 (02) :153-162