ELEVATION OF SKELETAL-MUSCLE ISOFORM OF SERUM CREATINE-KINASE IN HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

被引：8

作者：

BHATNAGAR, D

DURRINGTON, PN

NEARY, R

MILLER, JP

机构：

[1] UNIV MANCHESTER, MANCHESTER ROYAL INFIRM, DEPT CHEM PATHOL, MANCHESTER M13 9WL, LANCS, ENGLAND

[2] UNIV HOSP S MANCHESTER, DEPT MED, MANCHESTER M20 8LR, LANCS, ENGLAND

来源：

JOURNAL OF INTERNAL MEDICINE | 1990年 / 228卷 / 05期

关键词：

creatine kinase; familial hypercholesterolaemia; muscle;

D O I：

10.1111/j.1365-2796.1990.tb00268.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abstract. Serum creatine kinase (CK) is an important adjunct in the diagnosis of myocardial infarction or in monitoring for the side‐effects of drugs. We report elevation of CK in patients with untreated heterozygous familial hypercholesterolaemia (FH) with no evidence of myocardial infarction. Of a group of 30 patients, 60% had elevated CK values on one occasion. In 40% of patients elevated CK activity was observed on most occasions. This was not related to exercise or previous lipid‐lowering therapy. These observations are of importance in view of the potential for misdiagnosis of myocardial infarction or premature withdrawal of lipid‐lowering therapy. 1990 Blackwell Publishing Ltd

引用

页码：493 / 495

页数：3

共 7 条

[1] INVESTIGATION OF SERUM CREATINE-KINASE VARIABILITY AFTER MUSCLE-DAMAGING EXERCISE [J].