PROSTAGLANDIN AND THROMBOXANE BIOSYNTHESIS

被引：372

作者：

SMITH, WL ^{[1
]}

MARNETT, LJ ^{[1
]}

DEWITT, DL ^{[1
]}

机构：

[1] VANDERBILT UNIV, MED CTR,SCH MED,CTR MOLEC TOXICOL,DEPT BIOCHEM, AB HANCOCK JR MEM LAB CANC RES, NASHVILLE, TN 37232 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 1991年 / 49卷 / 03期

关键词：

D O I：

10.1016/0163-7258(91)90054-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We describe the enzymological regulation of the formation of prostaglandin (PG) D2, PGE2, PGF2-alpha, 9-alpha, 11-beta-PGF2, PGI2 (prostacyclin), and thromboxane (Tx) A2 from arachidonic acid. We discuss the three major steps in prostanoid formation: (a) arachidonate mobilization from monophosphatidyl-inositol involving phospholipase C, diglyceride lipase, and monoglyceride lipase and from phosphatidyl-choline involving phospholipase A2; (b) formation of prostaglandin endoperoxides (PGG2 and PGH2) catalyzed by the cyclooxygenase and peroxidase activities of PGH synthase; and (c) synthesis of PGD2, PGE2, PGF2-alpha, 9-alpha, 11-beta-PGF2, PGI2, and TxA2 from PGH2. We also include information on the roles of aspirin and other nonsteroidal anti-inflammatory drugs, dexamethasone and other anti-inflammatory steroids, platelet-derived growth factor (PDGF), and interleukin-1 in prostaglandin metabolism.

引用

页码：153 / 179

页数：27

共 246 条

[71]

GLASER KB, 1990, J BIOL CHEM, V265, P8658

[72] SN-1,2-DIACYLGLYCEROLS AND PHORBOL DIESTERS STIMULATE THROMBOXANE SYNTHESIS BY DENOVO SYNTHESIS OF PROSTAGLANDIN-H SYNTHASE IN HUMAN PROMYELOCYTIC LEUKEMIA-CELLS [J].

GOERIG, M ;

HABENICHT, AJR ;

HEITZ, R ;

ZEH, W ;

KATUS, H ;

KOMMERELL, B ;

ZIEGLER, R ;

GLOMSET, JA .

JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (03) :903-911

[73]

GOERIG M, 1988, J BIOL CHEM, V263, P19384

[74]

GOLDYNE ME, 1983, ADV PROSTAG THROMB L, V12, P39

[75] PROSTACYCLIN SYNTHASE, A CYTOCHROME-P450 ENZYME [J].

GRAF, H ;

RUF, HH ;

ULLRICH, V .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1983, 22 (06) :487-488

[76] EFFECT OF PROTEIN-SYNTHESIS INHIBITORS ON GROWTH-FACTOR ACTIVATION OF C-FOS, C-MYC, AND ACTIN GENE-TRANSCRIPTION [J].

GREENBERG, ME ;

HERMANOWSKI, AL ;

ZIFF, EB .

MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (04) :1050-1057

[77] KININ-INDUCED PROSTAGLANDIN SYNTHESIS BY RENAL PAPILLARY COLLECTING TUBULE CELLS IN CULTURE [J].

GRENIER, FC ;

ROLLINS, TE ;

SMITH, WL .

AMERICAN JOURNAL OF PHYSIOLOGY, 1981, 241 (01) :F94-F104

[78] INTERRELATIONSHIPS AMONG PROSTAGLANDINS, VASOPRESSIN AND CAMP IN RENAL PAPILLARY COLLECTING TUBULE CELLS IN CULTURE [J].

GRENIER, FC ;

ALLEN, ML ;

SMITH, WL .

PROSTAGLANDINS, 1982, 24 (04) :547-565

[79]

GRONICH JH, 1988, J BIOL CHEM, V263, P16645

[80] HUMAN PLATELET-DERIVED GROWTH-FACTOR STIMULATES PROSTAGLANDIN SYNTHESIS BY ACTIVATION AND BY RAPID DENOVO SYNTHESIS OF CYCLOOXYGENASE [J].

HABENICHT, AJR ;

GOERIG, M ;

GRULICH, J ;

ROTHE, D ;

GRONWALD, R ;

LOTH, U ;

SCHETTLER, G ;

KOMMERELL, B ;

ROSS, R .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 75 (04) :1381-1387

← 3 4 5 6 7 8 9 10 11 12 →