DOMOIC ACID, AN ENVIRONMENTAL TOXIN, PRODUCES HIPPOCAMPAL DAMAGE AND SEVERE MEMORY IMPAIRMENT

被引：70

作者：

SUTHERLAND, RJ

HOESING, JM

WHISHAW, IQ

机构：

[1] Department of Psychology, The University of Lethbridge, Lethbridge, Alta.

来源：

NEUROSCIENCE LETTERS | 1990年 / 120卷 / 02期

基金：

英国医学研究理事会; 加拿大自然科学与工程研究理事会;

关键词：

NEUROTOXICITY; DOMOIC ACID; EXCITATORY AMINO ACID; GLUTAMATE RECEPTOR; ANTEROGRADE AMNESIA; SPATIAL MEMORY; MUSSEL; SHELLFISH;

D O I：

10.1016/0304-3940(90)90043-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microinjections of domoic acid, a presumed shellfish toxin, into the hippocampal formation of rats produces degeneration of CA3 and CA1 pyramidal cells and dentate gyrus granule cells. We demonstrate that domoate-treated rats exhibit a long-lasting anterograde amnesia for spatial information in the Morris water task. This preparation provides a good model for examining neurotoxicity and the anterograde amnesic syndrome observed in humans following consumption of domoate-contaminated shellfish.

引用

页码：221 / 223

页数：3

共 10 条

[1] DOMOIC ACID, THE ALLEGED MUSSEL TOXIN, MIGHT PRODUCE ITS NEUROTOXIC EFFECT THROUGH KAINATE RECEPTOR ACTIVATION - AN ELECTROPHYSIOLOGICAL STUDY IN THE RAT DORSAL HIPPOCAMPUS [J].