THE GROWTH INHIBITORY-ACTION OF MELATONIN ON HUMAN BREAST-CANCER CELLS IS LINKED TO THE ESTROGEN RESPONSE SYSTEM

被引：128

作者：

HILL, SM

SPRIGGS, LL

SIMON, MA

MURAOKA, H

BLASK, DE

机构：

[1] ABILENE CHRISTIAN UNIV, DEPT BIOL, ABILENE, TX 79601 USA

[2] MARY IMOGENE BASSETT HOSP, RES INST, COOPERSTOWN, NY 13326 USA

来源：

CANCER LETTERS | 1992年 / 64卷 / 03期

关键词：

ANTIPROLIFERATIVE EFFECT; BREAST CANCER CELLS; MELATONIN; ESTROGEN RESPONSE PATHWAY;

D O I：

10.1016/0304-3835(92)90050-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The pineal hormone, melatonin, was examined for its capacity to modulate the proliferation of a panel of human breast cancer cell lines. Melatonin inhibited, to a varying extent, the proliferation of all three estrogen-responsive cell lines, but had no effect on estrogen-insensitive breast tumor cell lines. Melatonin was also able to specifically block estrogen-induced proliferation in MCF-7 breast cancer cells. However, this action was abolished in the presence of tamoxifen. Therefore, it appears that the antiproliferative effects of melatonin are mediated through the estrogen-response pathway.

引用

页码：249 / 256

页数：8

共 17 条

[1] INHIBITORY EFFECTS OF THE PINEAL HORMONE MELATONIN AND UNDERFEEDING DURING THE PROMOTIONAL PHASE OF 7,12-DIMETHYLBENZANTHRACENE-(DMBA)-INDUCED MAMMARY TUMORIGENESIS [J].