OPTIMAL ELECTRIC CONDITIONS IN ELECTRICAL IMPULSE CHEMOTHERAPY

被引:62
作者
OKINO, M [1 ]
TOMIE, H [1 ]
KANESADA, H [1 ]
MARUMOTO, M [1 ]
ESATO, K [1 ]
SUZUKI, H [1 ]
机构
[1] NIHON MEDICUS CO LTD,INST MED ELECTR,MATSUDO 271,JAPAN
来源
JAPANESE JOURNAL OF CANCER RESEARCH | 1992年 / 83卷 / 10期
关键词
ELECTRICAL IMPULSE CHEMOTHERAPY; BLEOMYCIN; AH-109A HEPATOCELLULAR CARCINOMA; OPTIMAL ELECTRIC CONDITIONS;
D O I
10.1111/j.1349-7006.1992.tb02727.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The relationship was examined between the tumoricidal effect and the electrical variables of in vivo electrical impulse chemotherapy. Donryu rats subcutaneously inoculated with AH-109AY hepatocellular carcinomas were given a single high-voltage electrical impulse of varying voltage and duration, 30 min after an intramuscular injection of 4 mg/kg bleomycin. As the voltage (V) was increased from 0 to 5 kV, the tumoricidal effect (E) increased in proportion to the square of the voltage. As the pulse duration (D) was increased from 2.5 to 5.8 ms, the tumoricidal effect increased in direct proportion to it. Combining these results yielded the formula, E=gammaV2D, which indicates that tumoricidal efficacy was proportional to the applied electrical energy. When the electrical energy was kept constant while varying the voltage and duration of pulse, the anticancer effect was the same, confirming this relationship for lower energy levels.
引用
收藏
页码:1095 / 1101
页数:7
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