CADMIUM-ASSOCIATED RENAL-DISEASE

被引：35

作者：

SAVOLAINEN, H

机构：

[1] Institute of Occupational Health Sciences, University of Lausanne, Lausanne

来源：

RENAL FAILURE | 1995年 / 17卷 / 05期

关键词：

CADMIUM; KIDNEY; LIVER; METALLOTHIONEIN; BETA(2)-MICROGLOBULIN; NEPHROLITHIASIS; PROTEOGLYCANS; RETINOL BINDING PROTEIN; TUBULOPATHY;

D O I：

10.3109/08860229509037613

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Cadmium is widely used in industry, causing exposure of workers and environmental pollution because of its persistence in the biosystems. Its very long half-life in the human organism causes its accumulation over the lifetime in liver and kidneys. Cadmium ions have a high affinity for tissue thiols, induce the synthesis of a carrier cysteine-rich polypeptide called metallothionein, and impair proteoglycan metabolism. Significant renal effects include early tubular nephropathy manifested by proteinuria, amino aciduria, glucosuria, phosphaturia, and calcium wastage. Chronic sequels include decrease in the glomerular filtration rate and increased risk of kidney stone disease. Biological monitoring of cadmium absorption includes determination of urinaly cadmium and of low molecular weight marker proteins, such as beta(2)-microglobulin or retinol binding protein, the tubular reabsorption of which is impaired before a frank proteinuria.

引用

页码：483 / 487

页数：5

共 30 条

[1]

Erickson D., Cadmium charges, Sci Am, 264, (1991)

[2]

Iwata K., Saito H., Moriyama M., Nakano A., Association between renal tubular dysfunction and mortality among residents in a cadmium-polluted area, Tohoku J Exp Med, 164, pp. 93-102, (1992)

[3]

Iwata K., Saito H., Nakano A., Association between cadmium-induced renal dysfunction and mortality: Further evidence, Tohoku J Exp Med, 1654, pp. 319-330, (1991)

[4]

Pocock S.J., Delves H.T., Ashby D., Shaper A.G., Clayton B.E., Blood cadmium concentrations in general population of British middle-aged men, Hum Toxicol, 7, pp. 95-103, (1988)

[5]

Thun M.J., Elinder C.-G., Friberg L., Scientific basis for an occupational standard for cadmium, Am J Ind Med, 20, pp. 629-642, (1991)

[6]

Wing A.J., Brunner F.P., Geerlings W., Broyer M., Brynger H., Fassbinder W., Rissoni G., Selwood N.H., Tufveson G., Contribution of toxic nephropathies to end-stage renal failure in Europe: a report from the EDTA-ERA registry, Toxicol Lett, 46, pp. 281-292, (1989)

[7]

Davison A.G., Newman Taylor A.J., Darbyshire J., Guthrie C.J.G., O'Malley D., Mason H.J., Fayers P.M., Venables K.M., Pickering C.A.C., Franlin D., Scott M.C., Holden H., Wright A.L., Gompertz D., Cadmium fume inhalation and emphysema, Lancet, i, pp. 663-667, (1988)

[8]

Nordberg G.F., Jin T., Nordberg M., Subcellular targets of cadmium nephrotoxicity: cadmium binding to renal membrane proteins in animals with or without protective metallothionein synthesis, Envir Hlth Persp, 102, pp. 191-194, (1994)

[9]

Andersen O., Nielsen J.B., Sorensen J.A., Scherrebeck L., Experimental localization of intestinal uptake sites for metals (Cd, Hg, ZN, Se) in vivo in mice, Envir Hlth Persp, 102, pp. 199-206, (1994)

[10]

Vahter M., Berglung M., Lind B., Jorhem L., Slorach S., Friberg L., Personal monitoring of lead and cadmium exposure—a Swedish study with special reference to methodological aspects, Scand J Wk Envir Hlth, 17, pp. 65-74, (1991)

← 1 2 3 →