LOCALIZATION OF THE 75-KDA INOSITOL POLYPHOSPHATE-5-PHOSPHATASE (INPP5B) TO HUMAN-CHROMOSOME BAND-1P34

被引：6

作者：

JANNE, PA

DUTRA, AS

DRACOPOLI, NC

CHARNAS, LR

PUCK, JM

NUSSBAUM, RL

机构：

[1] NIH,NATL CTR HUMAN GENOME RES,GENET DIS RES LAB,BLDG 49-4A72,BETHESDA,MD 20892

[2] NICHHD,BETHESDA,MD

[3] UNIV PENN,SCH MED,DEPT GENET,PHILADELPHIA,PA 19104

来源：

CYTOGENETICS AND CELL GENETICS | 1994年 / 66卷 / 03期

关键词：

D O I：

10.1159/000133691

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The 75-kDa (type II) inositol polyphosphate-5-phosphatase, originally described in platelets, is one of at least three known enzymes capable of dephosphorylating inositol-1,4,5-trisphosphate (IP3) to inositol-1,4-bisphosphate (IP2). To further characterize these enzymatic forms, we have mapped the gene (INPP5B) coding for the 75-kDa type II enzyme, Using a combination of human x rodent somatic cell hybrids and fluorescence in situ hybridization, we have determined that this gene maps to human chromosome band 1p34.

引用

页码：164 / 166

页数：3

共 13 条

[1] THE LOWE OCULOCEREBRORENAL SYNDROME GENE ENCODES A PROTEIN HIGHLY HOMOLOGOUS TO INOSITOL POLYPHOSPHATE-5-PHOSPHATASE [J].